4BASEBIO PLC
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Cash
£18m
-48.6% vs 2024
Net assets
£10m
-61.7% first positive since 2023
Employees
122
+22% highest in 3 filed years
Profit before tax
-£18m
-39.1% lowest in 3 filed years
Watchouts
Facts from the Companies House register and the latest accounts — not a rating
-
Material uncertainty over going concern
We draw attention to note 2 in the financial statements, which indicates that there is uncertainty over the revenue forecast and, if required, over the timing and quantum of an additional fund raise... these events or conditions... indicate that a material uncertainty exists that may cast significant doubt on the Group and company's ability to continue as a going concern. Our opinion is not modified in respect of this matter.
-
Going-concern uncertainty disclosed
Net assets
3-year trend · vs Industrials median
Accounts
3-year trend · Δ = latest vs prior filed period · latest reflected 2025-12-31
| Metric | Trend | 2023-12-31 | 2024-12-31 | 2025-12-31 | Δ vs prior |
|---|---|---|---|---|---|
| Turnover | £506,000 | £933,000 | £1,693,000 | +81.5% | |
| Operating profit | -£8,052,000 | -£12,042,000 | -£17,600,000 | -46.2% | |
| Profit before tax | -£8,354,000 | -£12,654,000 | -£17,603,000 | -39.1% | |
| Net profit | -£7,665,000 | -£12,333,000 | -£16,905,000 | -37.1% | |
| Cash | £3,069,000 | £34,604,000 | £17,803,000 | -48.6% | |
| Total assets less current liabilities | £9,645,000 | £41,462,000 | £26,721,000 | -35.6% | |
| Net assets | -£492,000 | £26,380,000 | £10,111,000 | -61.7% | |
| Equity | -£492,000 | £26,380,000 | £10,111,000 | -61.7% | |
| Average employees | 77 | 100 | 122 | +22% | |
| Wages | £3,900,000 | £5,303,000 | £7,738,000 | +45.9% | |
| Directors' remuneration | £880,000 | £1,204,800 | £1,319,000 | +9.5% |
Values shown as filed in the company's annual accounts. — indicates the figure wasn't present under that line item in that period. The Δ column is the change from the prior filed period as a percentage of |prior|; lines a company doesn't report show —. About these numbers
Ratios
Computed from the line items above — sparklines read oldest → newest
| Ratio | Trend | 2023-12-31 | 2024-12-31 | 2025-12-31 |
|---|---|---|---|---|
| Return on capital employed | -83.5% | -29.0% | -65.9% | |
| Gearing (liabilities / total assets) | 104.1% | 41.0% | 65.8% | |
| Current ratio | 2.21x | 11.30x | 7.31x | |
| Interest cover | -26.66x | -16.01x | -19.84x |
Gearing is liabilities over total assets. Current ratio is current assets over creditors falling due within one year. Interest cover is operating profit over absolute finance costs. Margin ratios are hidden where reported turnover is too small relative to profit to yield a meaningful figure — typical of holding companies whose income is mostly subsidiary dividends rather than trading revenue. Sector-distribution context coming next.
Audit & accounting basis
- Accounting basis
- UK-adopted IFRS
- Reporting scope
- Consolidated group
- Auditor
- Crowe U.K. LLP
- Audit opinion
- Unqualified (clean)
- Going concern
- Material uncertainty disclosed
“We draw attention to note 2 in the financial statements, which indicates that there is uncertainty over the revenue forecast and, if required, over the timing and quantum of an additional fund raise... these events or conditions... indicate that a material uncertainty exists that may cast significant doubt on the Group and company's ability to continue as a going concern. Our opinion is not modified in respect of this matter.”
Group structure
- 4BASEBIO PLC · parent
- 4basebio S.L.U. 100%
- 4basebio UK Limited 100%
- 4basebio Discovery Limited 100%
- 4basebio Inc. 100%
Significant events
- “On 10 February 2026, the Company announced that Dr Amy Walker, previously Chief Operating Officer, had been appointed Chief Executive Officer with immediate effect, succeeding Dr Heikki Lanckriet, the Founder, who stepped down as Chief Executive Officer after six years in the role.”
- “On 3 March 2026, the Company announced that it had entered into a lease for a new innovation hub and manufacturing facility in Cambridge, UK, supporting growing demand for research and high-quality grade synthetic DNA manufacturing.”
- “On 27 April 2026, the Group received a countersigned drawdown notice in respect of a €7 million facility from 2Invest AG. Funds were received by the Group on 30 April 2026. The facility provides additional liquidity headroom for the Group over the going concern assessment period.”
Auditor, going-concern and subsidiary information is drawn from the narrative of the latest annual accounts. About these numbers
People
7 active · 6 resigned
| Name | Role | Appointed | Born | Nationality |
|---|---|---|---|---|
| BOERMAN, Manja Hermina Elisabeth Maria, Dr. | Director | 2025-07-08 | Jan 1966 | Dutch |
| LANCKRIET, Heikki, Dr. | Director | 2021-07-20 | May 1977 | Belgian |
| LINK, Alexander Christian Ansgar | Director | 2024-11-13 | Jul 1971 | German |
| MALUS, Alan | Director | 2024-12-16 | Nov 1959 | American |
| PLAGGEMARS, Hansjoerg | Director | 2024-11-13 | Jun 1970 | American |
| WALKER, Amy Jo, Dr. | Director | 2024-08-05 | Jul 1993 | British |
| WASSERMAN, Michael Jason, Dr | Director | 2024-11-13 | Sep 1974 | Canadian,American |
Show 6 resigned officers
| Name | Role | Appointed | Resigned |
|---|---|---|---|
| ROTH, David John | Secretary | 2021-07-20 | 2026-02-10 |
| DE LA HUERTA, Maria Del Pilar | Director | 2021-07-20 | 2024-11-13 |
| FERNANDEZ, Joseph | Director | 2021-07-20 | 2024-11-13 |
| MCCARTHY, Timothy Paul | Director | 2021-07-20 | 2025-07-07 |
| PLAGGEMARS, Hansjoerg | Director | 2021-07-20 | 2024-06-28 |
| ROTH, David John | Director | 2021-07-20 | 2026-02-10 |
Ownership
Persons with significant control
| Name | Kind | Nature of control | Notified | Status |
|---|---|---|---|---|
| 2invest Ag | Corporate entity | Shares 25–50%, Voting 25–50% | 2021-07-20 | Active |
Filing timeline
Last 20 of 38 total filings
Material constitutional events — rename, articles re-file, resolution
- 2026-07-13 RESOLUTIONS Resolution
| Date | Type | Category | Description | |
|---|---|---|---|---|
| 2026-07-25 | AA | accounts | Accounts with accounts type group | |
| 2026-07-13 | RESOLUTIONS | resolution | Resolution | |
| 2026-06-26 | TM01 | officers | Termination director company with name termination date | |
| 2026-06-26 | AP01 | officers | Appoint person director company with name date | |
| 2026-06-26 | TM01 | officers | Termination director company with name termination date | |
| 2026-06-03 | AP03 | officers | Appoint person secretary company with name date | |
| 2026-02-10 | TM01 | officers | Termination director company with name termination date | |
| 2026-02-10 | TM02 | officers | Termination secretary company with name termination date | |
| 2026-02-06 | CS01 | confirmation-statement | Confirmation statement with no updates | |
| 2026-02-05 | SH01 | capital | Capital allotment shares | |
| 2026-02-05 | SH01 | capital | Capital allotment shares | |
| 2025-07-14 | AP01 | officers | Appoint person director company with name date | |
| 2025-07-11 | TM01 | officers | Termination director company with name termination date | |
| 2025-06-17 | AA | accounts | Accounts with accounts type group | |
| 2025-05-14 | SH01 | capital | Capital allotment shares | |
| 2025-01-08 | CS01 | confirmation-statement | Confirmation statement with updates | |
| 2025-01-08 | AP01 | officers | Appoint person director company with name date | |
| 2024-11-28 | AP01 | officers | Appoint person director company with name date | |
| 2024-11-28 | AP01 | officers | Appoint person director company with name date | |
| 2024-11-28 | AP01 | officers | Appoint person director company with name date |
Public-record activity
Raw counts from Companies House — last 12–24 months
- Filings
- 11
- Capital events
- 3
- Officers appointed
- 0
- Officers resigned
- 2
last 12 months
last 24 months
last 12 months
last 12 months
Direct counts from the register. No score, no rating — see the Filing timeline for the underlying events.