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Cash

£18m

-48.6% vs 2024

Net assets

£10m

-61.7% first positive since 2023

Employees

122

+22% highest in 3 filed years

Profit before tax

-£18m

-39.1% lowest in 3 filed years

Watchouts

Facts from the Companies House register and the latest accounts — not a rating

Accounts

3-year trend · Δ = latest vs prior filed period · latest reflected 2025-12-31

Metric Trend 2023-12-312024-12-312025-12-31 Δ vs prior
Turnover £506,000£933,000£1,693,000 +81.5%
Operating profit -£8,052,000-£12,042,000-£17,600,000 -46.2%
Profit before tax -£8,354,000-£12,654,000-£17,603,000 -39.1%
Net profit -£7,665,000-£12,333,000-£16,905,000 -37.1%
Cash £3,069,000£34,604,000£17,803,000 -48.6%
Total assets less current liabilities £9,645,000£41,462,000£26,721,000 -35.6%
Net assets -£492,000£26,380,000£10,111,000 -61.7%
Equity -£492,000£26,380,000£10,111,000 -61.7%
Average employees 77100122 +22%
Wages £3,900,000£5,303,000£7,738,000 +45.9%
Directors' remuneration £880,000£1,204,800£1,319,000 +9.5%

Values shown as filed in the company's annual accounts. indicates the figure wasn't present under that line item in that period. The Δ column is the change from the prior filed period as a percentage of |prior|; lines a company doesn't report show . About these numbers

Ratios

Computed from the line items above — sparklines read oldest → newest

Ratio Trend 2023-12-312024-12-312025-12-31
Return on capital employed -83.5%-29.0%-65.9%
Gearing (liabilities / total assets) 104.1%41.0%65.8%
Current ratio 2.21x11.30x7.31x
Interest cover -26.66x-16.01x-19.84x

Gearing is liabilities over total assets. Current ratio is current assets over creditors falling due within one year. Interest cover is operating profit over absolute finance costs. Margin ratios are hidden where reported turnover is too small relative to profit to yield a meaningful figure — typical of holding companies whose income is mostly subsidiary dividends rather than trading revenue. Sector-distribution context coming next.

Audit & accounting basis

Accounting basis
UK-adopted IFRS
Reporting scope
Consolidated group
Auditor
Crowe U.K. LLP
Audit opinion
Unqualified (clean)
Going concern
Material uncertainty disclosed

“We draw attention to note 2 in the financial statements, which indicates that there is uncertainty over the revenue forecast and, if required, over the timing and quantum of an additional fund raise... these events or conditions... indicate that a material uncertainty exists that may cast significant doubt on the Group and company's ability to continue as a going concern. Our opinion is not modified in respect of this matter.”

Group structure

  1. 4BASEBIO PLC · parent
    1. 4basebio S.L.U. 100% · Spain · R&D and product development
    2. 4basebio UK Limited 100% · UK · DNA manufacture and commercial operations
    3. 4basebio Discovery Limited 100% · UK · R&D and product development
    4. 4basebio Inc. 100% · USA · US commercial operations

Significant events

Auditor, going-concern and subsidiary information is drawn from the narrative of the latest annual accounts. About these numbers

People

7 active · 6 resigned

Name Role Appointed Born Nationality
BOERMAN, Manja Hermina Elisabeth Maria, Dr. Director 2025-07-08 Jan 1966 Dutch
LANCKRIET, Heikki, Dr. Director 2021-07-20 May 1977 Belgian
LINK, Alexander Christian Ansgar Director 2024-11-13 Jul 1971 German
MALUS, Alan Director 2024-12-16 Nov 1959 American
PLAGGEMARS, Hansjoerg Director 2024-11-13 Jun 1970 American
WALKER, Amy Jo, Dr. Director 2024-08-05 Jul 1993 British
WASSERMAN, Michael Jason, Dr Director 2024-11-13 Sep 1974 Canadian,American
Show 6 resigned officers
Name Role Appointed Resigned
ROTH, David John Secretary 2021-07-20 2026-02-10
DE LA HUERTA, Maria Del Pilar Director 2021-07-20 2024-11-13
FERNANDEZ, Joseph Director 2021-07-20 2024-11-13
MCCARTHY, Timothy Paul Director 2021-07-20 2025-07-07
PLAGGEMARS, Hansjoerg Director 2021-07-20 2024-06-28
ROTH, David John Director 2021-07-20 2026-02-10

Ownership

Persons with significant control

Name Kind Nature of control Notified Status
2invest Ag Corporate entity Shares 25–50%, Voting 25–50% 2021-07-20 Active

Filing timeline

Last 20 of 38 total filings

Material constitutional events — rename, articles re-file, resolution

  • 2026-07-13 RESOLUTIONS Resolution
Date Type Category Description
2026-07-25 AA accounts Accounts with accounts type group
2026-07-13 RESOLUTIONS resolution Resolution
2026-06-26 TM01 officers Termination director company with name termination date PDF
2026-06-26 AP01 officers Appoint person director company with name date PDF
2026-06-26 TM01 officers Termination director company with name termination date PDF
2026-06-03 AP03 officers Appoint person secretary company with name date PDF
2026-02-10 TM01 officers Termination director company with name termination date PDF
2026-02-10 TM02 officers Termination secretary company with name termination date PDF
2026-02-06 CS01 confirmation-statement Confirmation statement with no updates PDF
2026-02-05 SH01 capital Capital allotment shares PDF
2026-02-05 SH01 capital Capital allotment shares PDF
2025-07-14 AP01 officers Appoint person director company with name date PDF
2025-07-11 TM01 officers Termination director company with name termination date PDF
2025-06-17 AA accounts Accounts with accounts type group
2025-05-14 SH01 capital Capital allotment shares PDF
2025-01-08 CS01 confirmation-statement Confirmation statement with updates PDF
2025-01-08 AP01 officers Appoint person director company with name date PDF
2024-11-28 AP01 officers Appoint person director company with name date PDF
2024-11-28 AP01 officers Appoint person director company with name date PDF
2024-11-28 AP01 officers Appoint person director company with name date PDF

Public-record activity

Raw counts from Companies House — last 12–24 months

Filings
11

last 12 months

Capital events
3

last 24 months

Officers appointed
0

last 12 months

Officers resigned
2

last 12 months

Direct counts from the register. No score, no rating — see the Filing timeline for the underlying events.

Official Companies House page